[Primary chemotherapy in operable breast carcinoma].

  title={[Primary chemotherapy in operable breast carcinoma].},
  author={Gianni Bonadonna and Pinuccia Valagussa},
  journal={Annali italiani di chirurgia},
  volume={70 3},
We have reviewed the current status of primary chemotherapy for resectable breast cancer. Available findings indicate that the most immediate benefit of this treatment approach consists in an important tumor shrinkage, enabling to significantly increase the rates of breast conserving approaches. In spite of the logical and scientific rationale, available data from prospective randomized studies do not provide evidence of a clear superiority of primary chemotherapy over adjuvant chemotherapy… CONTINUE READING