[Preparation of verapamil hydrochloride controlled-onset extended-release pellets and its pharmacokinetics in dogs].

@article{Chen2006PreparationOV,
  title={[Preparation of verapamil hydrochloride controlled-onset extended-release pellets and its pharmacokinetics in dogs].},
  author={Zhi-Peng Chen and Yan-yu Xiao and Hong-xuan Chen and Xi-jing Chen and La-rui Li and Jia-bi Zhu},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={2006},
  volume={41 8},
  pages={765-71}
}
AIM To prepare verapamil hydrochloride controlled-onset extended-release pellets (VH-COERP) and study its release behavior in vitro. To compare the pharmacokinetic characteristics and bioavailability in six Beagle dogs after oral administration of VH-COERP and verapamil hydrochloride delayed-release pellets (VH-DRP) as reference. METHODS The core of VH-COERP were prepared in the fluidized bed (mini-glatt) by spraying water solution containing drugs onto sucrose-starch pellets with hydroroxy… CONTINUE READING