[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].

  title={[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].},
  author={Yayoi Kawano and Akihiko Ito and Masanaho Sasatsu and Yoshiharu Machida},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={130 1},
Many orally disintegrating tablets have recently been developed to improve oral ingestion and usability and are widely administered clinically, resulting in improved quality of life for patients. Since orally disintegrating tablets rapidly disintegrate in the mouth, the masking of unpleasant taste is important. We investigated the masking of the taste of furosemide (FU) as a model drug with correctives and prepared orally disintegrating tablets. Using maltitol (MA) as a corrective, granules… Expand
Preparation and Evaluation of Taste Masked Orally Disintegrating Tablets with Granules Made by the Wet Granulation Method Using Mixtures of Yogurt Powder and Maltitol
We investigated the preparation of orally disintegrating tablets (ODTs) using furosemide (FU) as a model drug.Preparations were made from granules containing 2 correctives,maltitol (MA) and yogurtExpand
[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
YO was found to be a useful additive for masking unpleasant tastes and to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs) using the wet granulation method. Expand
Challenges and emerging solutions in the development of compressed orally disintegrating tablets
This review highlights the techniques used for developing modified-release ODTs, an emerging area in the field, and describes the poor flowability and segregation problems of directly compressed powders. Expand
Oral Disintegrating Tablets A Current Review
The patient compliance lies in the ease with which the drug is delivered into the body without affecting its efficacy and without causing any inconvenience to the patient. For the patients who have aExpand
Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride.
Novel freeze-dried orally disintegrating tablets for migraine therapy containing taste-masked naproxen sodium and naratriptan hydrochloride was developed and manufactured, facilitating buccal absorption of the active pharmaceutical ingredient. Expand
Optimized furosemide taste masked orally disintegrating tablets
The optimized ODTs formula showed good to acceptable taste in term of palatability, and in vivo disintegration time of this formula was about 10 s, which was complying with the pharmacopeia guidelines regarding hardness, friability, weight variation and content. Expand
Taste-masking effect of physical and organoleptic methods on peppermint-scented orally disintegrating tablet of famotidine based on suspension spray-coating method.
The results of this study suggest that different taste-masking mechanisms function cooperatively, and the combination of both taste- masking methods was most effective for improving palatability and VAS scores were similar to those of placebo ODTs. Expand
Orodispersible films and tablets with prednisolone microparticles.
  • W. Brniak, Ewelina Maślak, R. Jachowicz
  • Materials Science, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2015
The aim of this study was to prepare and evaluate the microparticles intended to mask a bitter taste of the prednisolone and use them in further preparation of two orodispersible dosage forms and showed good mechanical resistance while maintaining excellent disintegration properties. Expand
Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children
Many pediatric patients require medications that are not available in age appropriate formulations, especially those with cardiovascular diseases. The use of a suitable vehicle is critical for theExpand
An innovative method for the preparation of high API-loaded hollow spherical granules for use in controlled-release formulation.
Results show that a new manufacturing technology for the simple and low-cost preparation of ideal CR granules with suitable particle strength, flowability, particle size distribution and density characteristics for blending with other excipients is developed. Expand


Preparation and evaluation of tablets rapidly disintegrating in saliva containing bitter-taste-masked granules by the compression method.
It is confirmed that the rapidly disintegrating tablets can be prepared using these taste-masked granules and excipients which are commonly used in tablet preparation. Expand
Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity.
In order to make a compressed tablet which can rapidly disintegrate in the oral cavity, microcrystalline cellulose and low-substituted hydroxypropylcellulose were used as disintegrants, andExpand
Formulation design of taste-masked particles, including famotidine, for an oral fast-disintegrating dosage form.
In this study, the taste-masking of famotidine, which could apply to any fast-disintegrating tablet, was investigated using the spray-dry method and confirmed that the Spray- dry method produced the most appropriate taste- masked particles for fast- Disintegrating dosage forms. Expand
Studies of rapidly disintegrating tablets in the oral cavity using co-ground mixtures of mannitol with crospovidone.
Adding co-ground mixture of D-mannitol and crospovidone is useful in enhancing hardness of the tablets that could not be achieved by addition of their individually ground mixture, and the improvement in the hardness was also observed when other saccharides and disintegrants were used. Expand
Formulation study for lansoprazole fast-disintegrating tablet. I. Effect of compression on dissolution behavior.
To decrease cleavage and crushing of the enteric layer, the effects of the combined ratio of methacrylic acid copolymer dispersion to ethyl acrylate-methyl methacrylate copolym dispersion and the concentration of triethyl citrate on the dissolution in the acid stage and the buffer stage were investigated. Expand
Drug‐delivery Products and the Zydis Fast‐dissolving Dosage Form *
  • H. Seager
  • Medicine
  • The Journal of pharmacy and pharmacology
  • 1998
Many patients find it difficult to swallow tablets and hard gelatin capsules and do not take their medication as prescribed, but such problems can be resolved by means of the Zydis dosage form which does not require water to aid swallowing. Expand
Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method.
It was found that particle size is an important factor for tablet preparation using microcrystalline cellulose and it is possible to prepare drugs such as acetaminophen and ascorbic acid in the tablet form using PH-NM-06 in combination with L-HPC as a good disintegrant at a low compression force. Expand
New method of preparing high-porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material
Compressed tablets of a water-soluble material, prepared using mannitol, did not rapidly dissolve in water since it is difficult for water to penetrate into the tablets due to their low porosity. ToExpand
New compressed tablet rapidly disintegrating in saliva in the mouth using crystalline cellulose and a disintegrant.
A new compressed tablet is formulated which is rapidly disintegrated and dissolved in the mouth without the need to drink water and rapid disintegration was obtained in vitro using various compounding ratios of crystalline cellulose to L-HPC. Expand
Stability of freeze-dried tablets at different relative humidities.
Packaging of freeze-dried tablets with PVC/aluminum blister packs, PVC/PVDC/al aluminum blister Packs, or closed containers did not offer protection against moisture uptake, mechanical strength loss, and structural collapse. Expand