[Preparation of diclofenac sodium controlled release pellets and multiple-dose evaluation in healthy volunteers].

@article{Long1996PreparationOD,
  title={[Preparation of diclofenac sodium controlled release pellets and multiple-dose evaluation in healthy volunteers].},
  author={Xiang Yu Long and Xian-wei Zeng and Rui-qin Lu and Shou ping Xu},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={1996},
  volume={31 3},
  pages={209-13}
}
The yield of pellets obtained in preparing diclofenac sodium (DC-Na) controlled release pellets was affected by the lactose/starch ratio of the feed granules, viscosity of the binding solution and residence time in the rolling pot. The pellet shape was found to be correlated with surface tension of the binding solution. The concentration and composition of the coating solution and pellet size distribution were responsible for the agglutination in coating. The controlled release pellets (CRP… CONTINUE READING