[Preparation and utility of glibenclamide suppository for hospital use].

  title={[Preparation and utility of glibenclamide suppository for hospital use].},
  author={Yusuke Takahashi and Masamitsu Iwata and Syoichi Shirotake and Kozo Takayama and Y. Machlda b H OnlShl Y Machida and Tsuneji Nagai},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={118 9},
Glibenclamide (GC) is widely used as an oral hypoglycemic drug in the treatment of non-insulin dependent diabetes mellitus (NIDDM). Since GC is usually taken for a long period, side effects and noncompliance are among the problems. In order to solve those problems, we prepared GC suppositories and examined their usefulness. Suppositories containing 4, 20, and 40 mg of GC were prepared and examined for drug release, drug absorption and blood glucose levels after the rectal administration of… CONTINUE READING