[Preparation and in vitro anti-hepatic fibrosis evaluation of herpetone nanosuspensions].

@article{Zuo2019PreparationAI,
  title={[Preparation and in vitro anti-hepatic fibrosis evaluation of herpetone nanosuspensions].},
  author={Jie Zuo and Cheng-ying Shen and Bao-de Shen and Y. Liu and Rui-na Zhong and Xiao Liu and Xiao-han Wang and H. Yuan},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2019},
  volume={44 6},
  pages={
          1164-1169
        }
}
  • Jie Zuo, Cheng-ying Shen, +5 authors H. Yuan
  • Published 2019
  • Chemistry, Medicine
  • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Herpetone( HPT) is a bioactive lignan extracted from Herpetospermum pedunculosum,which can protect liver,lower aminotransferase and inhibit hepatitis B virus. However,HPT has a poor oral bioavailability due to its poor water solubility. And there is no report about whether HPT has an anti-hepatic fibrosis activity. To improve the dissolution of HPT and study its anti-hepatic fibrosis activity and mechanism,the study group prepared herpetone nanosuspensions( HPT-NS) by the miniaturized media… Expand
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