A 16 days clofibride treatment in hyperlipaemic rabbit (fat supply), reduces hypertriglyceridemia and hypercholesterolemia. Heparine clearing reaction, performed on the 17th day, with the daily clofibride dose ingested in one time, is increased. The exaggerated intravascular lipids hydrolysis could explain, in part, the hypolipaemic action of clofibride.
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