• Corpus ID: 2846656

[Potentiating effect of secretin on cholecystokinin-stimulated exocrine pancreatic secretion in rats].

@article{Moriyoshi1989PotentiatingEO,
  title={[Potentiating effect of secretin on cholecystokinin-stimulated exocrine pancreatic secretion in rats].},
  author={Yuriko Moriyoshi},
  journal={Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology},
  year={1989},
  volume={86 10},
  pages={
          2425-33
        }
}
  • Y. Moriyoshi
  • Published 1 October 1989
  • Medicine
  • Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
The potentiating effect of secretin on cholecystokinin (CCK)-stimulated exocrine pancreatic secretion was studied in anesthetized rats. Intravenous infusion of CCK-8 in three different doses of 0.03, 0.06 and 0.12 micrograms/kg-hr increased pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs dose-dependently. Simultaneous infusion of CCK-8 with secretin in a dose of 0.03 CU/kg-hr produced statistically greater pancreatic secretion of volume, bicarbonate, amylase and trypsin… 
1 Citations
Effects of KSG-504, a new cholecystokinin-A-receptor antagonist, on pancreatic exocrine and endocrine secretions in rats.
TLDR
In vivo studies suggest that KSG-504 has significant inhibitory effects both on the pancreatic exocrine and endocrine secretion stimulating by CCK, but has no effect on the exocrine secretion stimulated by secretin.