[Potential interest in powerful and specific ligands for the histamine H3 receptor].

@article{Arrang1988PotentialII,
  title={[Potential interest in powerful and specific ligands for the histamine H3 receptor].},
  author={J. M. Arrang and Monique Garbarg and J C Lancelot and Jeanne Marie Lecomte and H{\'e}l{\`e}ne Pollard and M. Robba and Walter Schunack and J-C. Schwartz},
  journal={Allergie et immunologie},
  year={1988},
  volume={20 9},
  pages={
          327-9, 331
        }
}
In contrast to cerebral histamine H1 and H2-receptors, histamine H3-receptors are presynaptically located on histamine-synthesizing nerve terminals (autoreceptors) and control the synthesis and release of the amine in cerebral neurons. Two imidazole derivatives were designed to interact at H3-receptors: (R) alpha-methylhistamine (alpha-MeHA), a chiral agonist, and thioperamide, a competitive antagonist derived from imidazolyl piperidine, both display high selectivity and potency at nanomolar… CONTINUE READING