[Porphyria cutanea tarda and hepatoerythropoietic porphyria].

  title={[Porphyria cutanea tarda and hepatoerythropoietic porphyria].},
  author={Suguru Nonaka and Atsushi Takamiyagi},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  volume={53 6},
Porphyria cutanea tarda (PCT) is induced by an enzyme deficiency of hepatic uroporphyrinogen decarboxylase activity. As the result of this enzyme deficiency, uroporphyrin and coproporphyrin accumulate to the skin and other organs. These porphyrins are excreted into urine because of their easy solubility in water. Exposure to the sunlight of the porphyrin-rich skin induces cutaneous changes. Porphyria cutanea tarda develops mainly in middle-aged males, sometimes in females. Ethylalcohol… CONTINUE READING