[Plasma and tissue concentration of ceftriaxone following a one-time i.v. dose of 2 g].

@article{Kttel1988PlasmaAT,
  title={[Plasma and tissue concentration of ceftriaxone following a one-time i.v. dose of 2 g].},
  author={J C K{\"u}ttel and Panajotis Petropoulos and Charles Crevoisier},
  journal={Schweizerische medizinische Wochenschrift},
  year={1988},
  volume={118 20},
  pages={786-8}
}
The concentration of ceftriaxon found in plasma and in fatty, muscular and colonic tissue after a single intravenous dose of 2 g are reported. 20 patients undergoing elective surgery of the colon were divided into five groups of 4, and ceftriaxon was given 45 min, 3, 6, 12 and 24 h before surgery. Even after 24 h the plasma and tissue concentrations were above MIC 90 for most microorganisms sensitive to ceftriaxon.