[Physiopathology of severe sepsis].

  title={[Physiopathology of severe sepsis].},
  author={Vincent Caille and Philippe Bossi and David Grimaldi and Antoine Vieillard-Baro},
  journal={Presse medicale},
  volume={33 4},
  pages={256-61; discussion 269}
Regarding the definition. Severe sepsis associates an explosive inflammatory reaction and organ failure. It is secondary to bacterial, fungal or viral infection. It can be at the origin of acute circulatory failure (state of septic shock). Response of the organism to infection. The presence of certain components of the membrane of pathogenic agents induces the release of various mediators in cascade, notably cytokines. Toll-like receptors (10 cloned in humans) intervene in the detection of… CONTINUE READING


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