[Pharmacotherapy in resistance depression].

  title={[Pharmacotherapy in resistance depression].},
  author={Jan Lestina and Jan Libiger},
  journal={Ceska a slovenska psychiatrie},
  volume={91 4},
This article reviews pharmacological approaches used to overcome treatment resistance in patients with serious unipolar depressive disorders. Resistant depression is defined as depression the symptoms of which persist despite adequate treatment. Main causes of unsuccessful treatment are incorrect diagnosis, inadequate duration of treatment or inadequate dosage. Other reasons for resistance are also discussed in the article. There are three basic strategies in treatment of resistance… CONTINUE READING

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