[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors].

@article{Endou1991PharmacologicalAO,
  title={[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors].},
  author={Masayuki Endou},
  journal={[Hokkaido igaku zasshi] The Hokkaido journal of medical science},
  year={1991},
  volume={66 5},
  pages={
          677-93
        }
}
  • Masayuki Endou
  • Published in
    [Hokkaido igaku zasshi] The Hokkaido journal of…
    1991
The interactions of the antiarrhythmic agents, disopyramide (D) and its congeners, pirmenol (Pr) and pentisomide (Pt), with peripheral muscarinic receptors (m-AchR) were investigated using binding and functional assays. D, Pr and Pt inhibited the specific binding of [3H]-N-methyl scopolamine ([3H]-NMS) to membrane fractions prepared from guinea pig left atria (LA), submandibular glands (SG) and urinary bladders (UB) in a concentration-dependent manner. Computer-assisted analysis showed that the… CONTINUE READING