Corpus ID: 22355610

[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].

  title={[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].},
  author={H. Blehov{\'a} and J. Mety{\vs}},
  journal={Ceskoslovenska farmacie},
  volume={41 6},
  • H. Blehová, J. Metyš
  • Published 1992
  • Chemistry, Medicine
  • Ceskoslovenska farmacie
  • Dithiadenoxide, a product of metabolic S-oxidation of the H1-antihistaminic agent dithiaden (bisulepin, Dithiaden), is also an effective histaminic H1-antagonist in pharmacological experiments in in vivo conditions. In contrast to dithiaden, dithiadenoxide exerts a demonstrable inhibitory action as much as the subtoxic or sublethal dosage in experiments in mice and rats. Its acute toxicity in mice and guinea-pigs substantially decreases; acute toxicological findings in rats are not unambiguous… CONTINUE READING

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