[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].
@article{Blehov1992PharmacologicPO,
title={[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].},
author={Hana Blehov{\'a} and Jan Mety{\vs}},
journal={Ceskoslovenska farmacie},
year={1992},
volume={41 6},
pages={
185-90
}
}Dithiadenoxide, a product of metabolic S-oxidation of the H1-antihistaminic agent dithiaden (bisulepin, Dithiaden), is also an effective histaminic H1-antagonist in pharmacological experiments in in vivo conditions. In contrast to dithiaden, dithiadenoxide exerts a demonstrable inhibitory action as much as the subtoxic or sublethal dosage in experiments in mice and rats. Its acute toxicity in mice and guinea-pigs substantially decreases; acute toxicological findings in rats are not unambiguous…