[Pharmacologic action of diuretics in the kidney].

  title={[Pharmacologic action of diuretics in the kidney].},
  author={Paolo Ferrari and Felix J. Frey},
  journal={Therapeutische Umschau. Revue therapeutique},
  volume={57 6},
The currently available diuretics increase the urinary excretion of sodium chloride by selective inhibition of specific sodium transporters in the loop of Henle and distal nephron. In recent years, the molecular cloning of the distal diuretic-sensitive sodium transporters has improved our understanding of the cellular mechanisms of action of each class of diuretics. The identification of mutations in the genes encoding these transporters in inherited disorders characterized by altered salt… CONTINUE READING