Corpus ID: 41370006

[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].

@article{Staak1978PharmacokineticSO,
  title={[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].},
  author={Michael Staak and A. Moosmayer},
  journal={Arzneimittel-Forschung},
  year={1978},
  volume={28 7},
  pages={
          1187-91
        }
}
Pharmacokinetic investigations concerning possible interactions of an orally administered single dosage of 20 mg dipotassium clorazepate and ethanol were conducted with 14 male subjects. Blood alcohol concentrations did not appear to be influenced by dipotassium clorazepate or its metabolites nordiazepam and oxazepam. The increase in oxazepam glucuronide excreted in the urine, however, was statistically significant. Nordiazepam concentration in the serum differed considerably between the group… Expand
1 Citations
Effects of Ethanol on Drug and Metabolite Pharmacokinetics
TLDR
Pharmacokinetic interactions of ethanol with other drugs, including its effects upon drug metabolite disposition, are reviewed in terms of clearance concepts to help understand the mechanisms of ethanol-drug interactions. Expand