• Corpus ID: 6406786

[Pharmacokinetic studies of a new fluorinated pyrimidine, 590-S (PH-FU), in human patients].

@article{1986PharmacokineticSO,
  title={[Pharmacokinetic studies of a new fluorinated pyrimidine, 590-S (PH-FU), in human patients].},
  author={},
  journal={Gan to kagaku ryoho. Cancer \& chemotherapy},
  year={1986},
  volume={13 6},
  pages={
          2193-8
        }
}
  • Published 1986
  • Medicine
  • Gan to kagaku ryoho. Cancer & chemotherapy
590-S (PH-FU) has a chemical structure of 1-(3-oxo-1, 3-dihydro-1-isobenzofranyl)-5-fluorouracil, which belongs to the fluorinated pyrimidine group. Preclinical studies of the drug revealed better a therapeutic index compared with that of Tegafur. The preclinical pharmacokinetic studies revealed a steep increase and rapid decrease of 590-S and activated 5-FU in the blood compared with those of other fluorinated pyrimidines. We performed pharmacokinetic studies on patients using oral…