[Pharmacokinetic and clinical evaluations of imipenem/cilastatin sodium in neonates and premature infants].

@article{Motohiro1989PharmacokineticAC,
  title={[Pharmacokinetic and clinical evaluations of imipenem/cilastatin sodium in neonates and premature infants].},
  author={Takashi Motohiro and Yuh Sakata and Kimiko Oda and Akiko Kawakami and Kaori Tanaka and Takeharu Koga and Yasuyuki Shimada and Shigehisa Tomita and Tomoko Fujimoto and Kazunori Tominaga},
  journal={The Japanese journal of antibiotics},
  year={1989},
  volume={42 5},
  pages={1102-24}
}
Pharmacokinetic and clinical studies on imipenem/cilastatin sodium (IPM/CS), a beta-lactam antibiotic of the carbapenem class and its renal dehydropeptidase-I inhibitor in a 1:1 ratio, were performed in neonates, premature infants and an infant. IPM/CS was administered intravenously to 4 neonates and 5 premature infants at a dose level of 10 mg/kg. Plasma levels and urinary excretion of IPM and CS were determined in 2 neonates and 2 premature infants after 30-minute infusion, and in 2 neonates… CONTINUE READING