[Persistence of type 1 human immunodeficiency virus (HIV-1) in MT-4 cells in presence of alpha-interferon].

@article{Selimova2001PersistenceOT,
  title={[Persistence of type 1 human immunodeficiency virus (HIV-1) in MT-4 cells in presence of alpha-interferon].},
  author={Ludmila M Selimova and S N Iordanskiĭ and E V Kazennova and Alexander Bobkov},
  journal={Voprosy virusologii},
  year={2001},
  volume={46 2},
  pages={17-20}
}
The development of HIV infection during serial passages of HIV-1 strains with different replication capacity was studied in the presence of natural human alpha-interferon (IFN-alpha). The virus activity was evaluated by accumulation of virus-specific proteins in cells and culture fluid, determined by Western blot method and analysis of viral DNA in the cells by polymerase chain reaction. IFN-alpha suppressed replication of HIV-1/IIIB and 1974. The replication of strain 1974 (with a 10-fold… CONTINUE READING