[Parenteral administration of diphenylhydantoin in the pre- and post-operative course on plasma level measurement].

@article{Ishikawa1982ParenteralAO,
  title={[Parenteral administration of diphenylhydantoin in the pre- and post-operative course on plasma level measurement].},
  author={Makoto Ishikawa and Hajime Handa and Akira Maeda and Takashi Koshikawa and Shunji Kitazawa and Reiko Hori},
  journal={No shinkei geka. Neurological surgery},
  year={1982},
  volume={10 10},
  pages={1077-83}
}
In the neurosurgical care, postoperative convulsion, the especially in the early postoperative course, is one of major complications because it can spoil an otherwise good surgical result. The present study was intended to investigate the prophylactic use of anticonvulsants on chemical measurement of their plasma levels. Parenteral diphenylhydantoin (DPH) given just before craniotomy failed to maintain high level of DPH in the postoperative course even with pretreatment of oral DPH. On the… CONTINUE READING

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