[PI3K/Akt/mTOR signaling pathway and non-small cell lung cancer].

  title={[PI3K/Akt/mTOR signaling pathway and non-small cell lung cancer].},
  author={QI Huiwei and Lihong Fan},
  journal={Zhongguo fei ai za zhi = Chinese journal of lung cancer},
  volume={13 12},
Lung cancer is one of the leading causes of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for about 75%-85% of all lung cancers. NSCLC often presents at stages too late for surgical intervention and traditional treatments including chemotherapy and radiotherapy are inadequate. The 5-year survival rate of NSCLC is only 5%-10%. PI3K/Akt/mTOR signaling pathway is an important intracellular signal transduction pathway. It plays an important role in cell apoptosis… CONTINUE READING
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