• Corpus ID: 38584202

[Oxidative stress in perioperative period of cesarean section].

@article{Burlev2014OxidativeSI,
  title={[Oxidative stress in perioperative period of cesarean section].},
  author={A V Burlev and V A Burlev and N A Il'iasova and Efim Munevich Shifman},
  journal={Anesteziologiia i reanimatologiia},
  year={2014},
  volume={59 6},
  pages={
          23-8
        }
}

• A. V. Burlev, V. Burlev, +1 author E. Shifman
• Published 2014
• Medicine
• Anesteziologiia i reanimatologiia

OBJECTIVE
To assess a pro- and antioxidant status in pregnant women at the system level in the perioperative period of cesarean section under regional and general anaesthesia.

MATERIAL AND METHODS
62 pregnant women aged 21 to 37 years (30,9 ± 6,2 y,ears) undergone delivery by cesarean section under general (n = 33) and regional (29) anaesthesia (1-2 class ASA (American Society ofAnesthesiologists). Blood samples were collected immediately after placing patients on an operating table (T1), immediately after suturing the surgical wound (T2), and 12 (T3) and 24 (T4) hours after taking the first sample. We studied following parameters: superoxide dismutase (SOD), glutathione peroxidase (GP). reduced glutathione (RG), total antioxidant activity, active products that react with thiobarbituric acid (TBA-ap).

RESULTS
In general anaesthesia cesarean critical period activation ofprooxidant and antlioxidant activity is the period T2. Activation prooxidant activity (TBA-ap) was stored at 12 and 24 hours after surgery. Increased antioxidant activity (SOD, GP) was observed in the period T2. which wass replaced by its inhibition to 24 hours. Reduced glutathione content (RG) was reduced during T2 remains at low values up to 24 hours. Regional anaesthesia did not change observed prooxidant (poorly marked increase antioxidant activity (SOD, GP), which persists up to 24 hours). Reduced glutathione content (RG) was reduced in the period T3. but recovered after 24 hours.

CONCLUSION
The use of regional imnaesthesia and spontaneous breathing with atmospheric air during an elective caesarean section helps to avoid induction and manifestations of oxidative stress in pregnant women in the perioperative period and to fully implement the program early activation parturients after cesarean section.