[Ox-LDL down-regulates expression of pigment epithelium-derived factor in human umbilical vein endothelial cells].

@article{Liu2014OxLDLDE,
  title={[Ox-LDL down-regulates expression of pigment epithelium-derived factor in human umbilical vein endothelial cells].},
  author={Jie Liu and Shu-tong Yao and Lei Zhai and Yue-Long Feng and Guo-Hua Song and Yang Yu and Ping Zhu and Shu-cun Qin},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2014},
  volume={66 4},
  pages={
          489-95
        }
}
Pigment epithelium-derived factor (PEDF) is a multifunctional protein with anti-inflammatory, antioxidant and antithrombotic properties and plays a protective role against atherosclerosis (AS). The purpose of the present study is to explore the effects of oxidized low density lipoprotein (ox-LDL) on the expression of PEDF in cultured human umbilical vein endothelial cells (HUVECs). HUVECs were cultured and incubated with ox-LDL at different concentrations (6.25, 12.5, 25, 50, 100 and 150 mg/L… CONTINUE READING