[Overexpression of c-erbB-2 gene product is associated with poor prognosis factors in breast carcinoma].

@article{Cianga2003OverexpressionOC,
  title={[Overexpression of c-erbB-2 gene product is associated with poor prognosis factors in breast carcinoma].},
  author={Corina Maria Cianga and Petru Cianga and Laurette Gratziela Cozma and Carmen C Diaconu and Eugen Carasevici},
  journal={Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi},
  year={2003},
  volume={107 2},
  pages={349-53}
}
Oncogenes, the abnormal forms of proto-oncogenes, were shown to be involved in malignant transformation and in tumor progression. c-erbB2/HER2/neu is member of EGFR family and encodes the p185 protein, which functions as a tyrosine-kinase. Gene amplification and/or p185 overexpression were reported to be associated with poor prognostic in cancer. Our… CONTINUE READING