[Osteoradionecrosis. I. Etiology, pathogenesis, clinical aspects and risk factors].

  title={[Osteoradionecrosis. I. Etiology, pathogenesis, clinical aspects and risk factors].},
  author={H. J. Thiel},
  journal={Radiobiologia, radiotherapia},
  volume={30 5},
  • H. J. Thiel
  • Published 1989 in Radiobiologia, radiotherapia
In curative therapy of mouth-cavity and oropharyngeal carcinomas the osteoradionecrosis has to be accepted as a calculated risk with an incidence of 4-35%. It is the question of a radio-caused bone death that comes about by progressive and irreversible morphological alterations at bones and at vessels: Loss of osteocytes, active osteoblasts and osteoclasts (hypocellularity), injury of normal bone metabolism, slackening of regeneration process, extreme susceptibility to infections of the… CONTINUE READING

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