[On the origin of meiotic errors with special reference to trisomy 21 (author's transl)].


The origin of the supernumetary chromosome 21 in Down's syndrome was traced by the use of polymorphic regions of this chromosome. The present results interpretated in the light of the extensive literature may be summarized as follows; 1. The meiotic error involved in trisomy 21 can take place in both sexes and occurs at random. It occurs twice as frequently… (More)


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