[Ocular hypotensive action of l-stepholidine].

Ocular hypotension was made by iv 20% NaCl 2.5 ml/kg in rabbits. On this model, l-stepholidine (l-SPD) lowered intraocular pressure when administered topically to the eyes. The ocular hypotensive action of 0.5% l-SPD was weaker than that of 0.5% timolol, but stronger than that of 0.5% pilocarpine. The maximal actions of the 3 drugs were similar. There were… CONTINUE READING