[Non invasive gene therapy in neurological diseases].

  title={[Non invasive gene therapy in neurological diseases].},
  author={Jos{\'e} Miguel Brito-Armas and Javier Castro-Hern{\'a}ndez and Mait{\'e} Rodr{\'i}guez-D{\'i}az and Rafael Castro-Fuentes},
  journal={Revista de neurologia},
  volume={52 10},
INTRODUCTION Brain gene therapy consists of introducing nucleic acids into nerve tissue whose expression may prove to be therapeutically useful. This genetic material is indirectly introduced by means of non invasive gene therapy into the blood thereby avoiding its direct injection into the brain and the damage to the blood brain barrier. AIM The different non invasive vectors and means of gene transfer to the central nervous system will be discussed. DEVELOPMENT There has been a remarkable… CONTINUE READING