• Corpus ID: 26935137

[Non-SU, insulin secretagogues].

  title={[Non-SU, insulin secretagogues].},
  author={M. Kikuchi},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  volume={57 3},
  • M. Kikuchi
  • Published 1 March 1999
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
The chemical structures, mechanisms of actions, bioavailabilities, insulinotrophic and hypoglycemic actions, and clinical trials of three novel oral hypoglycemic agents, NN-623, A-4166 and KAD-1229 are overviewed. They are non-SU insulin secretagogues and they induce quicker and shorter hypoglycemia than sulphonylureas do, presumably because they are rapidly absorbed into (Tmax: < 30 min) and excreted from blood (T 1/2: < 60 min). They bind to the SU-receptors and suppress K-ATP channels like… 
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