[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].

@article{Magnowski2010NoAB,
  title={[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region].},
  author={Piotr Magnowski and Agnieszka Seremak-Mrozikiewicz and Ewa Nowak-Markwitz and Grażyna Kurzawińska and Krzysztof Drews and Marek Spaczyński},
  journal={Ginekologia polska},
  year={2010},
  volume={81 7},
  pages={506-10}
}
BACKGROUND Increasing evidence indicates that genetic factors are involved in the process of carcinogenesis. BRCA 1 mutation has been proven to be responsible for increased risk of ovarian cancer However the importance of other genetic disorders, such as MTHFR polymorphism for increased risk of carcinogenesis, is still to be determined. Abnormal methylation seems to play a significant role in ovarian cancer pathogenesis. MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate into 5… CONTINUE READING