[New treatments for Raynaud's syndrome].

  title={[New treatments for Raynaud's syndrome].},
  author={Stefano Bellucci and Wallace Kedra and Nadine Ajzenberg and G{\'e}rard Tobelem and Jacques Philippe Caen},
  journal={Nouvelle revue francaise d'hematologie},
  volume={30 1-2},
Raynaud's phenomenon, either idiopathic or secondary is often severe. It is due to a vasospasm in response to cold, and an increase in sympathetic tone, hyperviscosity and sometimes hyperactivation of platelets and erythrocytes have been reported. New drugs have been developed such as ketanserin, which is a specific inhibitor of serotonin S2 receptors, and has led to a positive response in 38%-80% of patients. The prostaglandins PGE1 and PGI2 were given i.v. in refractory patients and led to a… CONTINUE READING