[Neurotransmitter ATP and cytokine release].

  title={[Neurotransmitter ATP and cytokine release].},
  author={Katsuko Morigiwa and Yasuichiro Fukuda and Motoyasu Yamashita},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={115 4},
Microglia, the resident macrophages in the central nervous system (CNS), are rapidly activated upon trauma or ischemic injury, releasing cytokines and undertaking tissue repair. Recent studies have indicated that CNS immune cells express ionotropic P2X and metabotropic P2Y purinoceptors and undergo functional changes in response to extracellular ATP. Non-stimulated cultured rat retinal microglia expressed metabotropic P2U(P2Y2, P2Y4) and ionotropic P2Z(P2X7) purinoceptors equally, whereas in… CONTINUE READING