[Neuronal apoptosis in human prion diseases].

  title={[Neuronal apoptosis in human prion diseases].},
  author={Françoise Gray and Homa Adle-Biassette and Fabrice C Chr{\'e}tien and T L Ereau and Marie-Bernadette Delisle and Claude Vital},
  journal={Bulletin de l'Academie nationale de medecine},
  volume={183 2},
  pages={305-20; discussion 320-1}
Neuronal loss is a salient feature of prion diseases; however, its causes and mechanisms are unclear. The possibility that it could occur through an apoptotic process has been postulated and this is consistent with the lack of inflammation in prion disorders as supported by experimental studies. In order to test this hypothesis in humans, we examined samples of frontal and temporal cerebral cortex, striatum, thalamus and cerebellum from 26 patients who died from prion diseases. They included 16… CONTINUE READING
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