[Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis].

@article{Misu2009NeuromyelitisOA,
  title={[Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis].},
  author={T. M. Misu and Toshiyuki Takahashi and Ichiro Nakashima and Kazuo Fujihara and Y. Itoyama},
  journal={Rinsho byori. The Japanese journal of clinical pathology},
  year={2009},
  volume={57 3},
  pages={262-70}
}
Neuromyelitis optica (NMO) is an inflammatory disease mainly affecting the optic nerve and spinal cord. There has been prolonged controversy over whether NMO is a subtype of multiple sclerosis (MS) or a distinct disease. Recently, a highly specific serum autoantibody marker, NMO-IgG, was exclusively found in the sera of NMO, and the target antigen was identified as the water channel protein aquaporin (AQP) 4. In our immunocytochemical assay using HEK293 cells transfected with human AQP4, we… CONTINUE READING