• Corpus ID: 6348208

[Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters].

@article{Eel2006NeurobiologyOA,
  title={[Neurobiology of alcohol withdrawal inhibitory and excitatory neurotransmitters].},
  author={Ertuǧrul Eşel},
  journal={Turk psikiyatri dergisi = Turkish journal of psychiatry},
  year={2006},
  volume={17 2},
  pages={
          129-37
        }
}
  • E. Eşel
  • Published 2006
  • Medicine
  • Turk psikiyatri dergisi = Turkish journal of psychiatry
Alcohol withdrawal is a syndrome that is the result of adaptive changes in the brain secondary to chronic alcohol use and is associated with changes in many neurotransmitter, neuropeptide, and hormonal systems. Long-term exposure to ethanol leads to an imbalance in different excitatory (especially glutamate, a major excitatory amino acid), and inhibitory neurotransmitter (especially GABA, a major inhibitory amino acid) systems. When alcohol consumption is reduced or completely ceases, these… 
Alteration of glutamate/GABA balance during acute alcohol withdrawal in emergency department: a prospective analysis.
TLDR
Low plasma levels of glutamate, GABA and glutamate/GABA ratio in alcoholic patients presenting with complicated AWS with the same values in non-alcohol abuser/dependent controls are measured to determine prognostic factors for severe withdrawal.
Cholinergic System and Oxidative Stress Changes in the Brain of a Zebrafish Model Chronically Exposed to Ethanol
TLDR
The cholinergic system and the oxidative balance were targeted by chronic ethanol toxicity, and this neurochemical regulatory mechanism may play an important role in understanding the effects of long-term ethanol consumption and tolerance in zebrafish model studies.
Ceftriaxone Attenuated Anxiety-Like Behavior and Enhanced Brain Glutamate Transport in Zebrafish Subjected to Alcohol Withdrawal
TLDR
Cef treatment in conjunction with EtOH withdrawal induced anxiolytic-like effects due to possible neuromodulation of glutamatergic transporters, potentially through mitigation of oxidative stress, and a significant reduction in brain sulfhydryl content in zebrafish subjected to EtOH withdrawals.
Investigation of pre-delirium and delirium in patients with alcohol withdraw
Abstract Introduction: Alcohol withdraw syndrome (AWS) and delirium tremens (DTs) are part of the clinical picture of alcohol dependence (AD). The mechanisms by which these conditions develop are not
Whole blood thiamine levels and its relationship with severity of alcohol withdrawal and neurological soft signs in patients with alcohol use disorder
TLDR
It may be concluded that low levels of whole blood thiamine is common in patient with alcohol use disorder and positively associated with quantity & duration of alcohol intake and Severity of alcohol withdrawal and soft neurological signs are not associated with whole bloodThiamine levels.
...
1
2
3
...

References

SHOWING 1-10 OF 78 REFERENCES
Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal.
TLDR
The data suggest that augmentation of excitatory neurotransmission may lead to enhanced oxidative stress, which, in concert with reduced inhibitory neurotransmission, may contribute to the symptoms of ethanol withdrawal and associated neurotoxicity in humans.
GABA systems, benzodiazepines, and substance dependence.
  • R. Malcolm
  • Medicine
    The Journal of clinical psychiatry
  • 2003
TLDR
Selective GABA agents with novel mechanisms of action have anxiolytic, anticonvulsant, and reward inhibition profiles that have potential in treating substance use and withdrawal and enhancing relapse prevention with less liability than benzodiazepines.
Chronic ethanol consumption:from neuroadaptation to neurodegeneration
Central nervous system mechanisms in alcohol relapse.
TLDR
The potential validity of this model is supported by the findings that acamprosate and naltrexone are effective in preventing the ADE in rodents, and both compounds have gained recognition for their therapeutic effects in clinical populations.
Alcoholism: allostasis and beyond.
  • G. Koob
  • Psychology, Medicine
    Alcoholism, clinical and experimental research
  • 2003
TLDR
The allostatic model not only integrates molecular, cellular, and circuitry neuroadaptations in brain motivational systems produced by chronic alcohol ingestion with genetic vulnerability but also provides a key to translate advances in animal studies to the human condition.
NMDA Receptor Antagonism and the Ethanol Intoxication Signal
Abstract: This paper reviews clinical evidence suggesting that antagonism of the N‐methyl‐d‐aspartate subtype of glutamate receptors by ethanol may convey an important component of the ethanol
Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
...
1
2
3
4
5
...