[Natural history of sickle cell anemia].

@article{Berchel1992NaturalHO,
  title={[Natural history of sickle cell anemia].},
  author={Colette Berchel and Jean Pierre Diara and H Loret and Lydia Foucan and C Le Turdu and Y Samuel},
  journal={La Revue du praticien},
  year={1992},
  volume={42 15},
  pages={1885-91}
}
Sickle-cell anaemia is characterized by three categories of clinical signs: anaemia, vaso-occlusive phenomena and infective complications, which are described here according to age. The natural history of the disease can be divided into four periods: the neonatal period which is asymptomatic but important to organize an effective protection; the first 5 years of life are characterized by a high risk of mortality, a high level of morbidity due to severe infections, episodes of acute anaemia and… CONTINUE READING