[Nasal mucosa and systemic repercussion of the topical and prolonged use of budesonide in patients with perennial allergic rhinitis].

@article{Aguado2000NasalMA,
  title={[Nasal mucosa and systemic repercussion of the topical and prolonged use of budesonide in patients with perennial allergic rhinitis].},
  author={Daniel L{\'o}pez Aguado and Daniel L{\'o}pez Campos and Luisa Aleyda Garcia Gonzalez and B P{\'e}rez Pi{\~n}ero and Mar{\'i}a Eugenia Campos Ba{\~n}ales},
  journal={Acta otorrinolaringologica espanola},
  year={2000},
  volume={51 8},
  pages={709-12}
}
In a prospective study, measurement of a 9.00 a.m. basal serum cortisol and biopsies of the inferior turbinate mucosa were taken from 40 patients using topical nasal corticosteroid (Budesonide) continuously for month or years. No systemic adverse effects and no histopathological changes of significance were found. These findings do no suggest that topically corticosteroids are harmful to the nasal mucosa and no produce systemic effects.