[NSAID--COX-2-inhibitors, where is the difference? Focus on the modes of action].


Non-steroidal anti-inflammatory drugs (NSAID) induce their action by inhibiting prostaglandin synthesis via the cyclooxygenase enzymes (COX). COX has recently been shown to have at least two isoforms, termed COX-1 and COX-2. The life-threatening gastrointestinal side effects of NSAID are caused by their inhibition of COX-1, which results in increased… (More)


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