[Myasthenia gravis: past, present and future].

  title={[Myasthenia gravis: past, present and future].},
  author={Hiroyuki Murai},
  journal={Rinsho shinkeigaku = Clinical neurology},
  volume={54 12},
Myasthenia gravis (MG) was first described in 17(th) century. It was after 1960s, when it became clear that MG was an autoimmune disease targeting AChR. Recently, anti-MuSK and anti-Lrp4 antibodies were found as novel antibodies in MG. In 1980s, in addition to cholinesterase inhibitors, high-dose corticosteroid treatment was introduced. This dramatically reduced the mortality rate of MG, but now we recognized that side effects of steroid have influenced patients significantly, and that high… CONTINUE READING
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