[Mutations of ret-proto-oncogene in thyroid medullary carcinoma].

  title={[Mutations of ret-proto-oncogene in thyroid medullary carcinoma].},
  author={Karin Frank-Raue and Wolfgang Hoeppner and H. J. Buhr and Christian Herfarth and Reinhard Ziegler and F Raue},
  journal={Deutsche medizinische Wochenschrift},
  volume={122 6},
OBJECTIVE To determine the importance of the molecular-genetic demonstration of germ-line mutation in the ret protooncogene for therapeutic measures in sporadic and hereditary medullary thyroid carcinoma (MTC). PATIENTS AND METHODS Several molecular-genetic tests were performed on DNA of 35 families with hereditary and 81 patients with the sporadic form of MTC (isolation of genomic DNA; PCR amplification; DNA sequencing: demonstration of mutation in codon 918 with restriction enzyme FOK 1… CONTINUE READING