• Corpus ID: 30817092

[Mutagenic effects of coal tar used in the treatment of psoriasis].

  title={[Mutagenic effects of coal tar used in the treatment of psoriasis].},
  author={D Gardosov{\'a} and V. Zvol{\'a}nekov{\'a} Mezencevov{\'a} and Ivan Kalina and F H{\'e}jj and Maciej Kopka and J Petrovicov{\'a}},
  journal={Bratislavske lekarske listy},
  volume={98 3},
BACKGROUND Pharmaceutic tar used in the treatment of psoriasis has a high contents of polycyclic aromatic carbohydrates which are considered to be carcinogenic. AIM The study is aimed at the estimation of the genotoxic risk arising from the treatment of psoriatic patients by pharmaceutic tar. The estimation is performed by biomonitoring. METHODS The used methods included: bacterial test on TA 98 strain of Salmonella typhimurium aimed at the assessment of mutagenity of urine and cytogenetic… 
Cytogenetic and immunological changes after dermal exposure to polycyclic aromatic hydrocarbons and UV radiation.
The study revealed that GT has a significant impact on both genetic and immunological parameters of psoriatic patients, and indicates that GT could increase genotoxic risk and modulates immunity of treated patients.
Selected immunological changes in patients with Goeckerman's therapy TNF-alpha, sE-selectin, sP-selectin, sICAM-1 and IL-8.
It is confirmed that pro-inflammatory chemokine (IL-8, IL-8) and adhesion molecules (sE-selectin, sP-select in, sICAM-1) play an important role in the development and regulation of inflammation in psoriasis.
Toxicological profile for wood creosote, coal tar creosote, coal tar, coal tar pitch, and coal tar pitch volatiles
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described therein, and identifies and reviews the key literature that describes a hazardous substance's toxicologic properties.
Possible genotoxic risk of combined exposure to pharmaceutical coal tar and UV-B radiation.
The study suggested the presence of an increased genotoxic risk from the therapy, and the PASI scores (Psoriasis Area and Severity Index) were monitored.