• Biology, Medicine
  • Published in
    Nihon rinsho. Japanese…
    2015

[Multiple myeloma stem cell].

@article{Hosen2015MultipleMS,
  title={[Multiple myeloma stem cell].},
  author={Naoki Hosen},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  year={2015},
  volume={73 1},
  pages={
          47-51
        }
}
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells. MM patients harbor phenotypic CD19+ B cells expressing the immunoglobulin gene sequence and the idiotype unique to the individual myeloma clone. However, in most MM patients CD19+ clonotypic B cells do not reconstitute MM disease upon transplantation into immune-deficient mice. In the SCID-rab and SCID-hu models, which enable engraftment of human MM in vivo, CD19-CD38++ plasma cells engrafted and rapidly… CONTINUE READING

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