Corpus ID: 45963292

[Multiple myeloma in siblings (contribution to the diagnosis, clinical aspects and etiology of plasmocytoma)].

  title={[Multiple myeloma in siblings (contribution to the diagnosis, clinical aspects and etiology of plasmocytoma)].},
  author={W. Hirsch and G. Schwarz},
  journal={Medizinische Klinik},
16 Citations

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Koinzidenz von familiär gehäuft auftretendem Plasmozytom, chronischer lymphatischer Leukämie und Rektumkarzinom
A case-report of a 68 year old man is given in whom chronic lymphatic leukemia, light-chain multiple myeloma, and carcinoma of the rectum were found simultaneously; the sister of the patient suffers from IgG-plasmocytoma. Expand
Multiple myeloma in two brothers. An immunochemical and immunogenetic familial study
Systematic immunochemical and immunogenetic studies in familial multipleMyeloma are proposed as a method to further elucidate an eventual genetic background in multiple myeloma. Expand
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Familial multiple myeloma. A review of thirty-seven families.
The review of the pertinent literature disclosed 36 reports of familial multiple myeloma, described mostly in siblings, to which the authors add one more family, raising the possibility of an environmental factor (virus?) which may contribute to the pathogenesis of Myeloma in genetically predisposed individuals. Expand
Epidemiology of Multiple Myeloma and Related Plasma Cell Disorders: An Analytic Review
The higher rate and earlier age of onset of myeloma in Blacks suggests an inborn susceptibility, although environmental factors cannot be excluded, and this may correlate with racial differences in baseline immunoglobulin levels 40 and with altered patterns of in vitro cellular response to mitogens in Blacks. Expand
Familial immunopathies. Report of nine families and survey of literature
Three individual cases of lanthanic paraproteinemia, discovered in a prospective study of 76 relatives of subjects with Immunopathies, suggest that there may be a higher frequency of immunopathies among family members than observed in the general population of comparable age. Expand
Familial myeloma. Report of eight families and a study of serum proteins in their relatives.
The high familial occurrence of this disease suggests the possibility of genetic factors in its etiology, and it is most important that a complete family history be obtained from patients with myeloma. Expand
Immunoglobulin analysis in families of myeloma patients.
Apparently myeloma differs in this respect from Waldenstrom's macroglobulinemia, which disease has been found preferentially to develop within families in which the immunoglobulin (IgM) producing cell system is improperly regulated and therefore presumably predisposed to neoplastic transformation. Expand
Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulins.
Thirty cases of monoclonal immunoglobulin disorders (paraproteinemias) not classifiable as multiple myeloma or Waldenstrom's macroglobulinemia are described and it is postulated that the secondary and primary-benign varieties represent the activity of "escaped" clones of immunoglOBulin-secreting cells with limited autonomy. Expand
Familial occurrence of M-components.
Two families with multiple occurrence of M-components are reported and the significance of genetic factors in these familial cases is discussed in relation to the known figures of the frequency of M -components and myeloma in Swedish populations. Expand