[Molecular structure and regulation of cyclooxygenase].

Abstract

Prostaglandin (PG) endoperoxide synthase is a bifunctional enzyme with fatty acid cyclooxygenase activity (arachidonic acid----PGG2) and PG hydroperoxidase activity (PGG2----PGH2). The primary structure of the enzyme was determined recently by cloning and sequencing the cDNAs for sheep and mouse enzymes and the genomic DNA for the human enzyme. Aspirin… (More)

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