[Molecular specificity of nafamostat mesilate (FUT), a drug used for the treatments of DIC and acute pancreatitis and as an anticoagulant--the pharmacodynamics and pharmacological action].

@article{Tsukagoshi2001MolecularSO,
  title={[Molecular specificity of nafamostat mesilate (FUT), a drug used for the treatments of DIC and acute pancreatitis and as an anticoagulant--the pharmacodynamics and pharmacological action].},
  author={Shigeru Tsukagoshi},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  year={2001},
  volume={28 9},
  pages={1237-43}
}
Pharmacokinetic studies of nafamostat mesilate (FUT) were reviewed in the previous report (Jpn J Cancer Chemother 27 (5): 767-774, 2000). In this report, the molecular specificity of FUT for these pharmacological behaviors were reviewed. In this study, it became clear that benzene ring inserted between ester-bond and guanidino group of the molecule and amidino group introduced in the opposite chain of guanidino group were found important for eliciting the molecular specificity of FUT. 

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