[Molecular pathogenesis of experimental membraneous glomerulonephritis (Heymann nephritis)].

@article{Kerjaschki1996MolecularPO,
  title={[Molecular pathogenesis of experimental membraneous glomerulonephritis (Heymann nephritis)].},
  author={Dontscho Kerjaschki},
  journal={Der Pathologe},
  year={1996},
  volume={17 4},
  pages={262-8}
}
The analysis and reassembly of the single steps in the pathogenesis of Heymann nephritis is reasonable well advanced, but still far from being comprehensive. It is established that antibodies against certain epitopes of the megalin/gp330 molecule or RAP are responsible for the formation of glomerular immune deposits. Apparently a second antibody antigen system targeting lipid antigens causes the activation of C5b-9, which triggers the biosynthesis of oxygen-radical-producing enzymes within… CONTINUE READING