[Molecular pathogenesis of chronic myeloid leukemia].


Chronic myeloid leukemia (CML) is a paradigm for neoplasias that are defined by a unique genetic aberration, the BCR-ABL1 fusion gene. CML is also the best example for molecular target therapy. The development of protein tyrosine kinase inhibitor, imatinib, has entirely changed the strategy of therapy for CML. Nonetheless, many fields of pathogenesis for… (More)


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@article{Sasaki2009MolecularPO, title={[Molecular pathogenesis of chronic myeloid leukemia].}, author={Ko Sasaki and Kinuko Mitani}, journal={Nihon rinsho. Japanese journal of clinical medicine}, year={2009}, volume={67 10}, pages={1894-9} }