[Molecular mechanisms inhibiting proliferation of myeloma cells].

  title={[Molecular mechanisms inhibiting proliferation of myeloma cells].},
  author={Yoshitaka Kikukawa and Yutaka Okuno and Hiroyuki Hata},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  volume={65 12},
Accumulating evidences suggest that many molecules are working as inhibitors of proliferation in myeloma cells e.g., PTEN, mTOR(PI3-kinase signal molecules), p53, RB1, INK4 family and KIP/CIP family (cell cycle check point molecules), PF4 (inhibitor of angiogenesis). In this review, significance of these molecules in myeloma is summarized. Additionally, our finding of growth inhibitory effect by PU.1 is explained.