[Molecular mechanism of glucocorticoid action].

  title={[Molecular mechanism of glucocorticoid action].},
  author={Alicja T Grzanka and Jerzy Jarząb and Barbara K Rogala},
  journal={Polskie Archiwum Medycyny Wewnetrznej},
  volume={95 4},
Glucocorticoids act on target cells via two isoforms of intracellular glucocorticoid receptors (GRs) called GRα (hormone-binding form) and GRβ which does not bind any glucocorticoids. A cycle of Hsp90 chaperone and co-chaperones maintains the functional status of GRs and their recycling. The binding of a glucocorticoid hormone to GRα leads to its activation… CONTINUE READING